Drug interactions
Chloramphenicol + Tolazamide
Severity: Moderate
Chloramphenicol and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may impair the hepatic metabolism of tolazamide, increasing its glucose-lowering effect. Hypoglycemia can occur.
What this interaction means in plain words
Chloramphenicol and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Tolazamide belongs to Endocrine.
Why it happens
Chloramphenicol inhibits hepatic enzymes that metabolize sulfonylureas, reducing tolazamide clearance.
What to do
Monitor blood glucose during concurrent therapy and after chloramphenicol is stopped. Reduce the tolazamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Chloramphenicol with Tolazamide?
MediHelp rates the interaction as moderate. Chloramphenicol and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol may impair the hepatic metabolism of tolazamide, increasing its glucose-lowering effect. Hypoglycemia can occur.
How serious is the interaction between Chloramphenicol and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during concurrent therapy and after chloramphenicol is stopped. Reduce the tolazamide dose if hypoglycemia occurs.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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