Drug interactions
Chloramphenicol + Umeclidinium-vilanterol
Severity: Minor
Chloramphenicol and Umeclidinium-vilanterol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol is reported to inhibit CYP3A4 and might raise vilanterol exposure, with more tachycardia, tremor and hypokalemia. The effect is not well characterized and is likely to be small.
What this interaction means in plain words
Chloramphenicol and Umeclidinium-vilanterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chloramphenicol belongs to Anti Bacterial; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Possible CYP3A4 inhibition reducing vilanterol metabolism.
What to do
No routine change is needed. Monitor heart rate, tremor and potassium if signs of beta-agonist excess appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Chloramphenicol
Frequently asked questions
Can I take Chloramphenicol with Umeclidinium-vilanterol?
MediHelp rates the interaction as minor. Chloramphenicol and Umeclidinium-vilanterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chloramphenicol is reported to inhibit CYP3A4 and might raise vilanterol exposure, with more tachycardia, tremor and hypokalemia. The effect is not well characterized and is likely to be small.
How serious is the interaction between Chloramphenicol and Umeclidinium-vilanterol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Monitor heart rate, tremor and potassium if signs of beta-agonist excess appear.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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