Drug interactions
Chloramphenicol + Vardenafil
Severity: Moderate
Chloramphenicol and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol inhibits hepatic drug metabolism and may increase vardenafil concentrations. This could increase adverse effects such as hypotension, headache and flushing.
What this interaction means in plain words
Chloramphenicol and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Vardenafil belongs to Genitourinary.
Why it happens
Chloramphenicol inhibits CYP3A4 and other hepatic enzymes, reducing vardenafil clearance.
What to do
Consider starting with a reduced vardenafil dose and monitor for hypotension and adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Chloramphenicol
Frequently asked questions
Can I take Chloramphenicol with Vardenafil?
MediHelp rates the interaction as moderate. Chloramphenicol and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol inhibits hepatic drug metabolism and may increase vardenafil concentrations. This could increase adverse effects such as hypotension, headache and flushing.
How serious is the interaction between Chloramphenicol and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider starting with a reduced vardenafil dose and monitor for hypotension and adverse effects.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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