Drug interactions
Chloramphenicol + Verapamil
Severity: Moderate
Chloramphenicol and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may inhibit CYP3A4 and increase verapamil concentrations. This can lead to excessive bradycardia, AV block or hypotension.
What this interaction means in plain words
Chloramphenicol and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Verapamil belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4-mediated verapamil metabolism by chloramphenicol.
What to do
Monitor heart rate, blood pressure and PR interval during co-administration. Reduce the verapamil dose if bradycardia or hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Chloramphenicol with Verapamil?
MediHelp rates the interaction as moderate. Chloramphenicol and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol may inhibit CYP3A4 and increase verapamil concentrations. This can lead to excessive bradycardia, AV block or hypotension.
How serious is the interaction between Chloramphenicol and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and PR interval during co-administration. Reduce the verapamil dose if bradycardia or hypotension occurs.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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