Drug interactions
Chloramphenicol + Voclosporin
Severity: Major
Chloramphenicol and Voclosporin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may increase voclosporin concentrations, raising the risk of nephrotoxicity, hypertension and neurotoxicity. Voclosporin has a narrow therapeutic margin.
What this interaction means in plain words
Chloramphenicol and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Voclosporin belongs to Miscellaneous.
Why it happens
CYP3A4 inhibition reduces voclosporin clearance.
What to do
Avoid if possible; otherwise monitor eGFR, blood pressure and potassium and reduce voclosporin dose as needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chloramphenicol
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Chloramphenicol with Voclosporin?
MediHelp rates the interaction as major. Chloramphenicol and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chloramphenicol may increase voclosporin concentrations, raising the risk of nephrotoxicity, hypertension and neurotoxicity. Voclosporin has a narrow therapeutic margin.
How serious is the interaction between Chloramphenicol and Voclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor eGFR, blood pressure and potassium and reduce voclosporin dose as needed.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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