Drug interactions
Chlordiazepoxide + Crofelemer
Severity: Minor
Chlordiazepoxide and Crofelemer: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer may inhibit CYP3A4 locally in the gut, which could modestly raise chlordiazepoxide exposure. Because crofelemer is barely absorbed, a systemic effect is unlikely and any increase in sedation would probably be small.
What this interaction means in plain words
Chlordiazepoxide and Crofelemer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlordiazepoxide belongs to Central Nervous System; Crofelemer belongs to Gastrointestinal Tract.
Why it happens
Possible inhibition of intestinal CYP3A4 by crofelemer, reducing first-pass metabolism of chlordiazepoxide.
What to do
No routine dose change is needed; watch for excess sedation or psychomotor impairment when crofelemer is started in patients on chlordiazepoxide.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlordiazepoxide and Crofelemer, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Chlordiazepoxide
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Chlordiazepoxide with Crofelemer?
MediHelp rates the interaction as minor. Chlordiazepoxide and Crofelemer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer may inhibit CYP3A4 locally in the gut, which could modestly raise chlordiazepoxide exposure. Because crofelemer is barely absorbed, a systemic effect is unlikely and any increase in sedation would probably be small.
How serious is the interaction between Chlordiazepoxide and Crofelemer?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; watch for excess sedation or psychomotor impairment when crofelemer is started in patients on chlordiazepoxide.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
