Drug interactions
Chlordiazepoxide + Fluconazole
Severity: Moderate
Chlordiazepoxide and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole may increase chlordiazepoxide exposure, leading to greater sedation, psychomotor impairment and respiratory depression. The risk is greater in older patients and with higher doses.
What this interaction means in plain words
Chlordiazepoxide and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Fluconazole belongs to Anti Fungals.
Why it happens
Fluconazole inhibits CYP3A4 and CYP2C19 metabolism of chlordiazepoxide.
What to do
Monitor for oversedation and reduce the benzodiazepine dose if needed. Warn patients about driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Chlordiazepoxide
Frequently asked questions
Can I take Chlordiazepoxide with Fluconazole?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole may increase chlordiazepoxide exposure, leading to greater sedation, psychomotor impairment and respiratory depression. The risk is greater in older patients and with higher doses.
How serious is the interaction between Chlordiazepoxide and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and reduce the benzodiazepine dose if needed. Warn patients about driving and alcohol.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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