Drug interactions
Chlordiazepoxide + Mirtazapine
Severity: Moderate
Chlordiazepoxide and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating, so combined use can cause marked drowsiness, impaired concentration and psychomotor performance. Falls and accidents are more likely, particularly in older adults.
What this interaction means in plain words
Chlordiazepoxide and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A potentiation (chlordiazepoxide) and histamine H1 antagonism (mirtazapine).
What to do
Start with low doses and counsel patients to avoid driving or hazardous tasks until response is known. Reduce doses in older adults and monitor for oversedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Chlordiazepoxide with Mirtazapine?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating, so combined use can cause marked drowsiness, impaired concentration and psychomotor performance. Falls and accidents are more likely, particularly in older adults.
How serious is the interaction between Chlordiazepoxide and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and counsel patients to avoid driving or hazardous tasks until response is known. Reduce doses in older adults and monitor for oversedation.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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