Drug interactions
Chlordiazepoxide + Pregabalin
Severity: Major
Chlordiazepoxide and Pregabalin: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pregabalin taken with a benzodiazepine adds to sedation, dizziness and cognitive and motor impairment. Respiratory depression is possible, especially in the elderly or in patients with respiratory compromise.
What this interaction means in plain words
Chlordiazepoxide and Pregabalin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlordiazepoxide belongs to Central Nervous System; Pregabalin belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS depression from GABAergic benzodiazepine action and pregabalin's effect on calcium channels.
What to do
Keep doses of both drugs as low as possible and monitor for oversedation and respiratory depression, particularly during initiation or titration. Warn patients about driving and alcohol.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Chlordiazepoxide
Other interactions of Pregabalin
Frequently asked questions
Can I take Chlordiazepoxide with Pregabalin?
MediHelp rates the interaction as major. Chlordiazepoxide and Pregabalin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pregabalin taken with a benzodiazepine adds to sedation, dizziness and cognitive and motor impairment. Respiratory depression is possible, especially in the elderly or in patients with respiratory compromise.
How serious is the interaction between Chlordiazepoxide and Pregabalin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep doses of both drugs as low as possible and monitor for oversedation and respiratory depression, particularly during initiation or titration. Warn patients about driving and alcohol.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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