Drug interactions
Chlordiazepoxide + Risperidone
Severity: Moderate
Chlordiazepoxide and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use can increase drowsiness and dizziness, and risperidone may add orthostatic hypotension. Older adults are at increased risk of falls.
What this interaction means in plain words
Chlordiazepoxide and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Risperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A potentiation and risperidone's antihistaminic and alpha-adrenergic blockade.
What to do
Use the lowest effective doses and monitor sedation and orthostatic blood pressure. Advise patients to avoid alcohol and hazardous activities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Chlordiazepoxide with Risperidone?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use can increase drowsiness and dizziness, and risperidone may add orthostatic hypotension. Older adults are at increased risk of falls.
How serious is the interaction between Chlordiazepoxide and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and orthostatic blood pressure. Advise patients to avoid alcohol and hazardous activities.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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