Drug interactions
Chlordiazepoxide + Rucaparib
Severity: Minor
Chlordiazepoxide and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak to moderate CYP3A4 inhibitor and may modestly raise chlordiazepoxide exposure. This could increase sedation, though the clinical effect is probably limited.
What this interaction means in plain words
Chlordiazepoxide and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlordiazepoxide belongs to Central Nervous System; Rucaparib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 metabolism of chlordiazepoxide by rucaparib.
What to do
Monitor for increased drowsiness and reduce the chlordiazepoxide dose if sedation appears.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlordiazepoxide
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Chlordiazepoxide with Rucaparib?
MediHelp rates the interaction as minor. Chlordiazepoxide and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a weak to moderate CYP3A4 inhibitor and may modestly raise chlordiazepoxide exposure. This could increase sedation, though the clinical effect is probably limited.
How serious is the interaction between Chlordiazepoxide and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased drowsiness and reduce the chlordiazepoxide dose if sedation appears.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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