Drug interactions
Chlordiazepoxide + Sevoflurane
Severity: Moderate
Chlordiazepoxide and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzodiazepines reduce the concentration of sevoflurane needed for anesthesia and increase cardiorespiratory depression. Hypotension and delayed emergence or recovery may occur.
What this interaction means in plain words
Chlordiazepoxide and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A receptor potentiation by both agents.
What to do
Anesthesia staff should titrate sevoflurane to effect and monitor hemodynamics, ventilation and depth of anesthesia. Anticipate possible prolonged recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Other interactions of Sevoflurane
Frequently asked questions
Can I take Chlordiazepoxide with Sevoflurane?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzodiazepines reduce the concentration of sevoflurane needed for anesthesia and increase cardiorespiratory depression. Hypotension and delayed emergence or recovery may occur.
How serious is the interaction between Chlordiazepoxide and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Anesthesia staff should titrate sevoflurane to effect and monitor hemodynamics, ventilation and depth of anesthesia. Anticipate possible prolonged recovery.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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