Drug interactions
Chlordiazepoxide + Stiripentol
Severity: Moderate
Chlordiazepoxide and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits several CYP enzymes and has additive CNS depressant effects with benzodiazepines, increasing sedation and somnolence. Its effect on chlordiazepoxide exposure is variable and not well characterized.
What this interaction means in plain words
Chlordiazepoxide and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Additive CNS depression plus stiripentol modulation of CYP3A4 and other enzymes.
What to do
Monitor for excessive sedation and for change in efficacy. Adjust the chlordiazepoxide dose according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Other interactions of Stiripentol
Frequently asked questions
Can I take Chlordiazepoxide with Stiripentol?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits several CYP enzymes and has additive CNS depressant effects with benzodiazepines, increasing sedation and somnolence. Its effect on chlordiazepoxide exposure is variable and not well characterized.
How serious is the interaction between Chlordiazepoxide and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and for change in efficacy. Adjust the chlordiazepoxide dose according to response.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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