Drug interactions
Chlordiazepoxide + Trazodone
Severity: Moderate
Chlordiazepoxide and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone is sedating and adds to benzodiazepine-related drowsiness and psychomotor impairment. Orthostatic hypotension may also contribute to dizziness and falls.
What this interaction means in plain words
Chlordiazepoxide and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and trazodone's H1, 5-HT2A and alpha-1 antagonism.
What to do
Use low initial doses and monitor sedation and orthostatic symptoms. Counsel patients to avoid driving until effects are known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Chlordiazepoxide with Trazodone?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone is sedating and adds to benzodiazepine-related drowsiness and psychomotor impairment. Orthostatic hypotension may also contribute to dizziness and falls.
How serious is the interaction between Chlordiazepoxide and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use low initial doses and monitor sedation and orthostatic symptoms. Counsel patients to avoid driving until effects are known.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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