Drug interactions
Chlordiazepoxide + Trimipramine
Severity: Moderate
Chlordiazepoxide and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimipramine is strongly sedating and antihistaminic, so combination with a benzodiazepine increases drowsiness and psychomotor impairment. Anticholinergic effects may add to confusion in older adults.
What this interaction means in plain words
Chlordiazepoxide and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and the antihistaminic and anticholinergic actions of trimipramine.
What to do
Use the lowest effective doses and monitor for oversedation, confusion and falls. Counsel on avoiding alcohol and hazardous tasks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Chlordiazepoxide with Trimipramine?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimipramine is strongly sedating and antihistaminic, so combination with a benzodiazepine increases drowsiness and psychomotor impairment. Anticholinergic effects may add to confusion in older adults.
How serious is the interaction between Chlordiazepoxide and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for oversedation, confusion and falls. Counsel on avoiding alcohol and hazardous tasks.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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