Drug interactions
Chlordiazepoxide-clidinium + Cimetidine
Severity: Moderate
Chlordiazepoxide-clidinium and Cimetidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine can raise chlordiazepoxide concentrations and prolong its half-life, leading to increased sedation and psychomotor impairment. The effect is most relevant in older patients and those with liver disease.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Cimetidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Cimetidine belongs to Gastrointestinal Tract.
Why it happens
Cimetidine inhibits hepatic CYP oxidative metabolism of chlordiazepoxide.
What to do
Monitor for oversedation and consider reducing the chlordiazepoxide dose, or use an alternative H2 blocker such as famotidine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Cimetidine?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Cimetidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cimetidine can raise chlordiazepoxide concentrations and prolong its half-life, leading to increased sedation and psychomotor impairment. The effect is most relevant in older patients and those with liver disease.
How serious is the interaction between Chlordiazepoxide-clidinium and Cimetidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and consider reducing the chlordiazepoxide dose, or use an alternative H2 blocker such as famotidine.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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