Drug interactions
Chlordiazepoxide-clidinium + Ciprofloxacin
Severity: Minor
Chlordiazepoxide-clidinium and Ciprofloxacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ciprofloxacin may modestly reduce the clearance of some benzodiazepines that undergo oxidative metabolism, such as chlordiazepoxide. This could increase sedation and psychomotor impairment, and fluoroquinolones may also add CNS stimulatory effects.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Ciprofloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Ciprofloxacin belongs to Anti Bacterial.
Why it happens
Ciprofloxacin inhibits CYP1A2 and possibly other oxidative pathways, slightly reducing benzodiazepine clearance.
What to do
No routine change is needed; monitor for excess sedation, particularly in older patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Ciprofloxacin?
MediHelp rates the interaction as minor. Chlordiazepoxide-clidinium and Ciprofloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ciprofloxacin may modestly reduce the clearance of some benzodiazepines that undergo oxidative metabolism, such as chlordiazepoxide. This could increase sedation and psychomotor impairment, and fluoroquinolones may also add CNS stimulatory effects.
How serious is the interaction between Chlordiazepoxide-clidinium and Ciprofloxacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor for excess sedation, particularly in older patients.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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