Drug interactions
Chlordiazepoxide-clidinium + Desipramine
Severity: Moderate
Chlordiazepoxide-clidinium and Desipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a tricyclic antidepressant with a benzodiazepine may increase drowsiness and psychomotor impairment, although desipramine is less sedating than many tricyclics. Additive anticholinergic effects with clidinium may also occur.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Desipramine belongs to Central Nervous System.
Why it happens
Additive CNS depression and additive anticholinergic effects.
What to do
Monitor for sedation and anticholinergic effects, particularly in older adults, and adjust doses if impairment occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Desipramine?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a tricyclic antidepressant with a benzodiazepine may increase drowsiness and psychomotor impairment, although desipramine is less sedating than many tricyclics. Additive anticholinergic effects with clidinium may also occur.
How serious is the interaction between Chlordiazepoxide-clidinium and Desipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and anticholinergic effects, particularly in older adults, and adjust doses if impairment occurs.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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