Drug interactions
Chlordiazepoxide-clidinium + Hydrocodone
Severity: Major
Chlordiazepoxide-clidinium and Hydrocodone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent benzodiazepine and opioid use increases the risk of profound sedation, respiratory depression, coma and death. Labeling for both drug classes carries boxed warnings. Elderly patients and those with lung disease are at highest risk.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Hydrocodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Hydrocodone belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression from GABA-A potentiation and mu-opioid receptor agonism.
What to do
Avoid unless alternatives are inadequate, then use the lowest effective doses for the shortest time. Monitor for sedation and respiratory depression, and consider naloxone availability.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Hydrocodone?
MediHelp rates the interaction as major. Chlordiazepoxide-clidinium and Hydrocodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Concurrent benzodiazepine and opioid use increases the risk of profound sedation, respiratory depression, coma and death. Labeling for both drug classes carries boxed warnings. Elderly patients and those with lung disease are at highest risk.
How serious is the interaction between Chlordiazepoxide-clidinium and Hydrocodone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless alternatives are inadequate, then use the lowest effective doses for the shortest time. Monitor for sedation and respiratory depression, and consider naloxone availability.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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