Drug interactions
Chlordiazepoxide-clidinium + Maprotiline
Severity: Moderate
Chlordiazepoxide-clidinium and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline combined with chlordiazepoxide increases sedation and psychomotor impairment. Maprotiline also lowers the seizure threshold and has anticholinergic activity that adds to clidinium effects.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Maprotiline belongs to Central Nervous System.
Why it happens
Additive CNS depression, plus additive anticholinergic effects between maprotiline and clidinium.
What to do
Monitor for oversedation, confusion, constipation, urinary retention, and dry mouth, and use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Maprotiline?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maprotiline combined with chlordiazepoxide increases sedation and psychomotor impairment. Maprotiline also lowers the seizure threshold and has anticholinergic activity that adds to clidinium effects.
How serious is the interaction between Chlordiazepoxide-clidinium and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation, confusion, constipation, urinary retention, and dry mouth, and use the lowest effective doses.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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