Drug interactions
Chlordiazepoxide-clidinium + Metaxalone
Severity: Moderate
Chlordiazepoxide-clidinium and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metaxalone adds to the sedative effect of chlordiazepoxide, which can impair alertness and coordination. The risk is greater in older adults and with higher doses.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Metaxalone belongs to Musculoskeletal.
Why it happens
Additive CNS depression from a centrally acting muscle relaxant and a benzodiazepine.
What to do
Use the lowest effective doses and counsel patients about driving and fall risk. Monitor for excessive drowsiness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Metaxalone
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Metaxalone?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metaxalone adds to the sedative effect of chlordiazepoxide, which can impair alertness and coordination. The risk is greater in older adults and with higher doses.
How serious is the interaction between Chlordiazepoxide-clidinium and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and counsel patients about driving and fall risk. Monitor for excessive drowsiness.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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