Drug interactions
Chlordiazepoxide-clidinium + Nalbuphine
Severity: Major
Chlordiazepoxide-clidinium and Nalbuphine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nalbuphine is an opioid agonist-antagonist, and combined with a benzodiazepine it can cause marked sedation and respiratory depression. Regulatory warnings about opioid-benzodiazepine combinations apply.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Nalbuphine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Nalbuphine belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression via kappa-opioid agonism and GABA-A potentiation.
What to do
Use the lowest effective doses for the shortest time and monitor sedation and respiratory rate closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Nalbuphine
- Alvimopan + Nalbuphine Contraindicated
- Nalbuphine + Olanzapine / samidorphan Contraindicated
- Alprazolam + Nalbuphine Major
- Amobarbital + Nalbuphine Major
- Benzhydrocodone / acetaminophen + Nalbuphine Major
- Brexanolone + Nalbuphine Major
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Nalbuphine?
MediHelp rates the interaction as major. Chlordiazepoxide-clidinium and Nalbuphine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nalbuphine is an opioid agonist-antagonist, and combined with a benzodiazepine it can cause marked sedation and respiratory depression. Regulatory warnings about opioid-benzodiazepine combinations apply.
How serious is the interaction between Chlordiazepoxide-clidinium and Nalbuphine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest time and monitor sedation and respiratory rate closely.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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