Drug interactions
Chloroquine + Cholera vaccine
Severity: Moderate
Chloroquine and Cholera vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloroquine may blunt the immune response to oral cholera vaccine, which could reduce protection for travellers. The vaccine labeling addresses this for live attenuated oral cholera vaccine.
What this interaction means in plain words
Chloroquine and Cholera vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chloroquine may reduce the immune response to the live oral vaccine, possibly by an effect on vaccine strain replication or immune activation.
What to do
Give the oral cholera vaccine at least 10 days before starting chloroquine prophylaxis. If that is not possible, consider an alternative prophylaxis or vaccine strategy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chloroquine and Cholera vaccine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Frequently asked questions
Can I take Chloroquine with Cholera vaccine?
MediHelp rates the interaction as moderate. Chloroquine and Cholera vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloroquine may blunt the immune response to oral cholera vaccine, which could reduce protection for travellers. The vaccine labeling addresses this for live attenuated oral cholera vaccine.
How serious is the interaction between Chloroquine and Cholera vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the oral cholera vaccine at least 10 days before starting chloroquine prophylaxis. If that is not possible, consider an alternative prophylaxis or vaccine strategy.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
