Drug interactions
Chloroquine + Conivaptan
Severity: Moderate
Chloroquine and Conivaptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a strong CYP3A4 inhibitor and may raise chloroquine concentrations, although chloroquine is only partly metabolized by CYP3A4. Higher chloroquine levels could add to QT prolongation and other toxicity.
What this interaction means in plain words
Chloroquine and Conivaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated chloroquine metabolism by conivaptan.
What to do
Monitor the ECG and watch for chloroquine toxicity if conivaptan is given; limit the conivaptan infusion duration as per labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Frequently asked questions
Can I take Chloroquine with Conivaptan?
MediHelp rates the interaction as moderate. Chloroquine and Conivaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Conivaptan is a strong CYP3A4 inhibitor and may raise chloroquine concentrations, although chloroquine is only partly metabolized by CYP3A4. Higher chloroquine levels could add to QT prolongation and other toxicity.
How serious is the interaction between Chloroquine and Conivaptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG and watch for chloroquine toxicity if conivaptan is given; limit the conivaptan infusion duration as per labeling.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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