Drug interactions
Chloroquine + Dabrafenib
Severity: Minor
Chloroquine and Dabrafenib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and other enzymes, which may lower chloroquine concentrations. The clinical impact is uncertain because chloroquine has multiple elimination pathways.
What this interaction means in plain words
Chloroquine and Dabrafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chloroquine belongs to Anti Parasitic; Dabrafenib belongs to Oncology.
Why it happens
Dabrafenib induces CYP3A4 and may increase the metabolism of chloroquine.
What to do
No empirical dose adjustment is needed. Monitor for reduced chloroquine effectiveness and consider an alternative if treating active malaria.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Chloroquine with Dabrafenib?
MediHelp rates the interaction as minor. Chloroquine and Dabrafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dabrafenib induces CYP3A4 and other enzymes, which may lower chloroquine concentrations. The clinical impact is uncertain because chloroquine has multiple elimination pathways.
How serious is the interaction between Chloroquine and Dabrafenib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose adjustment is needed. Monitor for reduced chloroquine effectiveness and consider an alternative if treating active malaria.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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