Drug interactions
Chloroquine + Dextroamphetamine
Severity: Minor
Chloroquine and Dextroamphetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloroquine inhibits CYP2D6, which contributes to amphetamine metabolism, so amphetamine levels may rise somewhat. The expected effect is small because renal elimination also plays a major role.
What this interaction means in plain words
Chloroquine and Dextroamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chloroquine belongs to Anti Parasitic; Dextroamphetamine belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by chloroquine reduces dextroamphetamine metabolism.
What to do
Monitor heart rate, blood pressure and stimulant adverse effects. Adjust the dextroamphetamine dose if signs of excess exposure appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Chloroquine with Dextroamphetamine?
MediHelp rates the interaction as minor. Chloroquine and Dextroamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chloroquine inhibits CYP2D6, which contributes to amphetamine metabolism, so amphetamine levels may rise somewhat. The expected effect is small because renal elimination also plays a major role.
How serious is the interaction between Chloroquine and Dextroamphetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and stimulant adverse effects. Adjust the dextroamphetamine dose if signs of excess exposure appear.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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