Drug interactions
Chloroquine + Erythromycin stearate
Severity: Major
Chloroquine and Erythromycin stearate: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both chloroquine and erythromycin prolong the QT interval, and erythromycin additionally inhibits CYP3A4. Combined use increases the risk of torsades de pointes.
What this interaction means in plain words
Chloroquine and Erythromycin stearate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation, with erythromycin CYP3A4 inhibition possibly raising chloroquine exposure.
What to do
Avoid if possible and choose a non-QT-prolonging antibiotic; if unavoidable, check ECG and electrolytes and monitor.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Frequently asked questions
Can I take Chloroquine with Erythromycin stearate?
MediHelp rates the interaction as major. Chloroquine and Erythromycin stearate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both chloroquine and erythromycin prolong the QT interval, and erythromycin additionally inhibits CYP3A4. Combined use increases the risk of torsades de pointes.
How serious is the interaction between Chloroquine and Erythromycin stearate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and choose a non-QT-prolonging antibiotic; if unavoidable, check ECG and electrolytes and monitor.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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