Drug interactions
Chloroquine + Gemtuzumab
Severity: Moderate
Chloroquine and Gemtuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents have been associated with QT interval prolongation. Concurrent use may increase the risk of ventricular arrhythmias, particularly in patients with electrolyte disturbances or heart disease.
What this interaction means in plain words
Chloroquine and Gemtuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check ECG and electrolytes before and during treatment. Correct hypokalemia and hypomagnesemia and avoid additional QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Frequently asked questions
Can I take Chloroquine with Gemtuzumab?
MediHelp rates the interaction as moderate. Chloroquine and Gemtuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents have been associated with QT interval prolongation. Concurrent use may increase the risk of ventricular arrhythmias, particularly in patients with electrolyte disturbances or heart disease.
How serious is the interaction between Chloroquine and Gemtuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes before and during treatment. Correct hypokalemia and hypomagnesemia and avoid additional QT-prolonging drugs.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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