Drug interactions
Chloroquine + Laronidase
Severity: Moderate
Chloroquine and Laronidase: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloroquine may interfere with cellular uptake of laronidase, reducing the enzyme's effectiveness in lysosomal targets.
What this interaction means in plain words
Chloroquine and Laronidase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloroquine belongs to Anti Parasitic; Laronidase belongs to Miscellaneous.
Why it happens
Chloroquine may inhibit receptor-mediated endocytosis of laronidase into lysosomes.
What to do
Avoid giving chloroquine at the same time as laronidase infusions. Consider an alternative antimalarial if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Frequently asked questions
Can I take Chloroquine with Laronidase?
MediHelp rates the interaction as moderate. Chloroquine and Laronidase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloroquine may interfere with cellular uptake of laronidase, reducing the enzyme's effectiveness in lysosomal targets.
How serious is the interaction between Chloroquine and Laronidase?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving chloroquine at the same time as laronidase infusions. Consider an alternative antimalarial if feasible.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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