Drug interactions
Chloroquine + Lofepramine
Severity: Moderate
Chloroquine and Lofepramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloroquine inhibits CYP2D6 and may increase levels of lofepramine and its active metabolite desipramine. This can increase anticholinergic and cardiac effects including QT prolongation.
What this interaction means in plain words
Chloroquine and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chloroquine inhibits CYP2D6-mediated metabolism of tricyclic compounds.
What to do
Monitor for tricyclic adverse effects and ECG changes; lower the lofepramine dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Frequently asked questions
Can I take Chloroquine with Lofepramine?
MediHelp rates the interaction as moderate. Chloroquine and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloroquine inhibits CYP2D6 and may increase levels of lofepramine and its active metabolite desipramine. This can increase anticholinergic and cardiac effects including QT prolongation.
How serious is the interaction between Chloroquine and Lofepramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic adverse effects and ECG changes; lower the lofepramine dose if needed.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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