Drug interactions
Chloroquine + Magaldrate
Severity: Moderate
Chloroquine and Magaldrate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antacids containing aluminium and magnesium can reduce the oral absorption of chloroquine. This may lead to lower drug levels and reduced efficacy.
What this interaction means in plain words
Chloroquine and Magaldrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Magaldrate is an antacid that binds chloroquine in the gut and raises gastric pH, which reduces its absorption.
What to do
Separate administration by at least 4 hours, giving chloroquine first where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Frequently asked questions
Can I take Chloroquine with Magaldrate?
MediHelp rates the interaction as moderate. Chloroquine and Magaldrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antacids containing aluminium and magnesium can reduce the oral absorption of chloroquine. This may lead to lower drug levels and reduced efficacy.
How serious is the interaction between Chloroquine and Magaldrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate administration by at least 4 hours, giving chloroquine first where possible.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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