Drug interactions
Chloroquine + Thiothixene
Severity: Moderate
Chloroquine and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloroquine and the antipsychotic thiothixene may both lengthen the QTc interval. Combined use raises the risk of serious ventricular arrhythmias such as torsades de pointes.
What this interaction means in plain words
Chloroquine and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation through blockade of cardiac potassium channels.
What to do
Check a baseline ECG and electrolytes, and monitor the QTc during co-administration. Prefer an alternative antimalarial or antipsychotic if the QTc is prolonged or other risk factors exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Frequently asked questions
Can I take Chloroquine with Thiothixene?
MediHelp rates the interaction as moderate. Chloroquine and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloroquine and the antipsychotic thiothixene may both lengthen the QTc interval. Combined use raises the risk of serious ventricular arrhythmias such as torsades de pointes.
How serious is the interaction between Chloroquine and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes, and monitor the QTc during co-administration. Prefer an alternative antimalarial or antipsychotic if the QTc is prolonged or other risk factors exist.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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