Drug interactions
Chloroquine + Trifluoperazine
Severity: Moderate
Chloroquine and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloroquine inhibits CYP2D6 and may modestly raise trifluoperazine exposure. In addition, both drugs can prolong the QT interval, so the combination may increase cardiac and extrapyramidal adverse effects.
What this interaction means in plain words
Chloroquine and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP2D6-mediated metabolism by chloroquine, plus additive QT prolongation.
What to do
Monitor for sedation, extrapyramidal symptoms and QTc prolongation, and reduce the trifluoperazine dose if adverse effects occur. Obtain an ECG if other QT-prolonging risks are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Frequently asked questions
Can I take Chloroquine with Trifluoperazine?
MediHelp rates the interaction as moderate. Chloroquine and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloroquine inhibits CYP2D6 and may modestly raise trifluoperazine exposure. In addition, both drugs can prolong the QT interval, so the combination may increase cardiac and extrapyramidal adverse effects.
How serious is the interaction between Chloroquine and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, extrapyramidal symptoms and QTc prolongation, and reduce the trifluoperazine dose if adverse effects occur. Obtain an ECG if other QT-prolonging risks are present.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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