Drug interactions
Chloroquine + Vilanterol / fluticasone furoate inhaled
Severity: Moderate
Chloroquine and Vilanterol / fluticasone furoate inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol is a long-acting beta-agonist that can cause tachycardia, hypokalemia and QTc prolongation, mainly at higher systemic exposure. With chloroquine, the arrhythmic potential may be somewhat greater, but at usual inhaled doses systemic exposure is low.
What this interaction means in plain words
Chloroquine and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, with beta-agonist induced hypokalemia that may further sensitize the myocardium.
What to do
Use only at labeled inhaled doses and check potassium in patients with cardiac risk factors. Obtain an ECG if palpitations or syncope occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Frequently asked questions
Can I take Chloroquine with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as moderate. Chloroquine and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol is a long-acting beta-agonist that can cause tachycardia, hypokalemia and QTc prolongation, mainly at higher systemic exposure. With chloroquine, the arrhythmic potential may be somewhat greater, but at usual inhaled doses systemic exposure is low.
How serious is the interaction between Chloroquine and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only at labeled inhaled doses and check potassium in patients with cardiac risk factors. Obtain an ECG if palpitations or syncope occur.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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