Drug interactions
Chlorothiazide + Enalapril-hydrochlorothiazide
Severity: Moderate
Chlorothiazide and Enalapril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorothiazide is a second thiazide diuretic, so combining it with a product that already contains hydrochlorothiazide duplicates therapy. This increases the risk of hypokalemia, hyponatremia, hypomagnesemia, volume depletion and hypotension, with limited added benefit.
What this interaction means in plain words
Chlorothiazide and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorothiazide belongs to Cardiovascular; Enalapril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive thiazide-mediated inhibition of sodium chloride reabsorption in the distal tubule, increasing urinary potassium, sodium and water loss.
What to do
Avoid therapeutic duplication of thiazides where possible. If used together, monitor serum electrolytes, renal function and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Enalapril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Chlorothiazide and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorothiazide is a second thiazide diuretic, so combining it with a product that already contains hydrochlorothiazide duplicates therapy. This increases the risk of hypokalemia, hyponatremia, hypomagnesemia, volume depletion and hypotension, with limited added benefit.
How serious is the interaction between Chlorothiazide and Enalapril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid therapeutic duplication of thiazides where possible. If used together, monitor serum electrolytes, renal function and blood pressure.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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