Drug interactions
Chlorothiazide + Fosinopril-hydrochlorothiazide
Severity: Moderate
Chlorothiazide and Fosinopril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorothiazide is another thiazide diuretic, so combining it duplicates therapy. This increases the risk of hypokalemia, hyponatremia, volume depletion and hypotension.
What this interaction means in plain words
Chlorothiazide and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorothiazide belongs to Cardiovascular; Fosinopril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Therapeutic duplication with additive inhibition of the sodium-chloride cotransporter and renal potassium loss.
What to do
Avoid concurrent use of two thiazides and stop one. If both are continued, monitor electrolytes and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Chlorothiazide and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorothiazide is another thiazide diuretic, so combining it duplicates therapy. This increases the risk of hypokalemia, hyponatremia, volume depletion and hypotension.
How serious is the interaction between Chlorothiazide and Fosinopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two thiazides and stop one. If both are continued, monitor electrolytes and renal function.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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