Drug interactions
Chlorothiazide + Indomethacin
Severity: Moderate
Chlorothiazide and Indomethacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indomethacin can reduce the diuretic and blood pressure lowering effects of chlorothiazide. The combination also raises the risk of renal impairment, particularly with dehydration.
What this interaction means in plain words
Chlorothiazide and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorothiazide belongs to Cardiovascular; Indomethacin belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal perfusion and sodium excretion, opposing the diuretic.
What to do
Monitor blood pressure, fluid balance, and renal function and electrolytes. Maintain hydration and use the lowest effective NSAID dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Indomethacin?
MediHelp rates the interaction as moderate. Chlorothiazide and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indomethacin can reduce the diuretic and blood pressure lowering effects of chlorothiazide. The combination also raises the risk of renal impairment, particularly with dehydration.
How serious is the interaction between Chlorothiazide and Indomethacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid balance, and renal function and electrolytes. Maintain hydration and use the lowest effective NSAID dose.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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