Drug interactions
Chlorothiazide + Ipratropium-salbutamol
Severity: Moderate
Chlorothiazide and Ipratropium-salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salbutamol shifts potassium into cells and chlorothiazide promotes renal potassium loss, so together they can cause clinically important hypokalemia. This is most relevant with high or repeated salbutamol dosing.
What this interaction means in plain words
Chlorothiazide and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorothiazide belongs to Cardiovascular; Ipratropium-salbutamol belongs to Respiratory.
Why it happens
Additive hypokalemia from beta-2 agonist-induced intracellular potassium shift and thiazide-induced renal potassium wasting.
What to do
Monitor serum potassium, particularly during exacerbations or high-dose nebulized therapy. Replace potassium and check magnesium if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Ipratropium-salbutamol?
MediHelp rates the interaction as moderate. Chlorothiazide and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salbutamol shifts potassium into cells and chlorothiazide promotes renal potassium loss, so together they can cause clinically important hypokalemia. This is most relevant with high or repeated salbutamol dosing.
How serious is the interaction between Chlorothiazide and Ipratropium-salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, particularly during exacerbations or high-dose nebulized therapy. Replace potassium and check magnesium if needed.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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