Drug interactions
Chlorothiazide + Linagliptin-metformin
Severity: Minor
Chlorothiazide and Linagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorothiazide can raise blood glucose and worsen glycemic control. This may blunt the effect of metformin and linagliptin.
What this interaction means in plain words
Chlorothiazide and Linagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorothiazide belongs to Cardiovascular; Linagliptin-metformin belongs to Endocrine.
Why it happens
Thiazide-induced hypokalemia and impaired insulin secretion and sensitivity oppose antidiabetic effects.
What to do
Monitor blood glucose and potassium after starting chlorothiazide. Adjust the antidiabetic dose if control deteriorates.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin-metformin
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Linagliptin-metformin?
MediHelp rates the interaction as minor. Chlorothiazide and Linagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chlorothiazide can raise blood glucose and worsen glycemic control. This may blunt the effect of metformin and linagliptin.
How serious is the interaction between Chlorothiazide and Linagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and potassium after starting chlorothiazide. Adjust the antidiabetic dose if control deteriorates.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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