Drug interactions
Chlorothiazide + Magnesium
Severity: Minor
Chlorothiazide and Magnesium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorothiazide can increase urinary magnesium loss and cause hypomagnesemia, mainly with prolonged use. Low magnesium may worsen hypokalemia and arrhythmia risk.
What this interaction means in plain words
Chlorothiazide and Magnesium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorothiazide belongs to Cardiovascular; Magnesium belongs to Gastrointestinal Tract.
Why it happens
Thiazides reduce renal tubular magnesium reabsorption, increasing urinary excretion.
What to do
Check serum magnesium and potassium periodically during long-term therapy. Supplement magnesium if deficient.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Magnesium
- Ciprofloxacin + Magnesium Major
- Magnesium + Pancuronium Major
- Magnesium + Rocuronium Major
- Magnesium + Vecuronium Major
- Amikacin + Magnesium Moderate
- Amphotericin b deoxycholate + Magnesium Moderate
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Magnesium?
MediHelp rates the interaction as minor. Chlorothiazide and Magnesium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chlorothiazide can increase urinary magnesium loss and cause hypomagnesemia, mainly with prolonged use. Low magnesium may worsen hypokalemia and arrhythmia risk.
How serious is the interaction between Chlorothiazide and Magnesium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum magnesium and potassium periodically during long-term therapy. Supplement magnesium if deficient.
What other medicines interact with Magnesium?
MediHelp also lists interactions of Magnesium with, for example, Ciprofloxacin, Pancuronium, Rocuronium. The full list is on the Magnesium page.
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