Drug interactions
Chlorothiazide + Mesalamine
Severity: Minor
Chlorothiazide and Mesalamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorothiazide is secreted by renal organic anion transporters and could theoretically reduce tubular clearance of mesalamine metabolites. Mesalamine can also be nephrotoxic, and diuretic-related volume depletion may add renal stress.
What this interaction means in plain words
Chlorothiazide and Mesalamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorothiazide belongs to Cardiovascular; Mesalamine belongs to Gastrointestinal Tract.
Why it happens
Theoretical competition for renal tubular organic anion secretion.
What to do
No empirical dose change is needed. Monitor renal function and hydration status during combined use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mesalamine
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Mesalamine?
MediHelp rates the interaction as minor. Chlorothiazide and Mesalamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chlorothiazide is secreted by renal organic anion transporters and could theoretically reduce tubular clearance of mesalamine metabolites. Mesalamine can also be nephrotoxic, and diuretic-related volume depletion may add renal stress.
How serious is the interaction between Chlorothiazide and Mesalamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor renal function and hydration status during combined use.
What other medicines interact with Mesalamine?
MediHelp also lists interactions of Mesalamine with, for example, Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Aceclofenac. The full list is on the Mesalamine page.
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