Drug interactions
Chlorothiazide + Nadolol
Severity: Moderate
Chlorothiazide and Nadolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents lower blood pressure, so the combination is often used intentionally but may cause additive hypotension. Thiazides can also cause hypokalemia, hyperglycemia and hyperuricemia, and beta blockers may mask hypoglycemia or worsen glucose control in diabetic patients.
What this interaction means in plain words
Chlorothiazide and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorothiazide belongs to Cardiovascular; Nadolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive pharmacodynamic effects, with thiazide-induced electrolyte and metabolic changes.
What to do
Monitor blood pressure, serum potassium and glucose, especially at initiation. Adjust doses of either drug if hypotension or electrolyte disturbance develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nadolol
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Nadolol?
MediHelp rates the interaction as moderate. Chlorothiazide and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents lower blood pressure, so the combination is often used intentionally but may cause additive hypotension. Thiazides can also cause hypokalemia, hyperglycemia and hyperuricemia, and beta blockers may mask hypoglycemia or worsen glucose control in diabetic patients.
How serious is the interaction between Chlorothiazide and Nadolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium and glucose, especially at initiation. Adjust doses of either drug if hypotension or electrolyte disturbance develops.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Amifostine. The full list is on the Nadolol page.
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