Drug interactions
Chlorothiazide + Nebivolol
Severity: Minor
Chlorothiazide and Nebivolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The two drugs are often combined for additive blood pressure control. Thiazide-induced hypokalemia, hyponatremia or hyperglycemia may need attention, and excessive hypotension is possible in volume-depleted patients.
What this interaction means in plain words
Chlorothiazide and Nebivolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorothiazide belongs to Cardiovascular; Nebivolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects through different mechanisms, with thiazide-related electrolyte loss.
What to do
Monitor blood pressure, serum potassium and sodium periodically, and glucose in diabetic patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Nebivolol?
MediHelp rates the interaction as minor. Chlorothiazide and Nebivolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The two drugs are often combined for additive blood pressure control. Thiazide-induced hypokalemia, hyponatremia or hyperglycemia may need attention, and excessive hypotension is possible in volume-depleted patients.
How serious is the interaction between Chlorothiazide and Nebivolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium and sodium periodically, and glucose in diabetic patients.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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