Drug interactions
Chlorothiazide + Oxaprozin
Severity: Moderate
Chlorothiazide and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the diuretic and antihypertensive effects of thiazides. Combined use also raises the risk of acute kidney injury, particularly with volume depletion.
What this interaction means in plain words
Chlorothiazide and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorothiazide belongs to Cardiovascular; Oxaprozin belongs to Musculoskeletal.
Why it happens
Inhibition of renal prostaglandin synthesis by oxaprozin causes sodium and water retention and lowers renal perfusion, opposing thiazide action.
What to do
Monitor blood pressure, renal function, fluid status and electrolytes. Use the lowest effective NSAID dose for the shortest duration and maintain hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Oxaprozin?
MediHelp rates the interaction as moderate. Chlorothiazide and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the diuretic and antihypertensive effects of thiazides. Combined use also raises the risk of acute kidney injury, particularly with volume depletion.
How serious is the interaction between Chlorothiazide and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function, fluid status and electrolytes. Use the lowest effective NSAID dose for the shortest duration and maintain hydration.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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