Drug interactions
Chlorothiazide + Regorafenib
Severity: Minor
Chlorothiazide and Regorafenib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regorafenib inhibits BCRP and could raise exposure to BCRP substrates. Chlorothiazide is not a well-established BCRP substrate, so a meaningful effect is doubtful.
What this interaction means in plain words
Chlorothiazide and Regorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorothiazide belongs to Cardiovascular; Regorafenib belongs to Oncology.
Why it happens
Regorafenib may inhibit BCRP-mediated transport of chlorothiazide.
What to do
No routine action is needed. Monitor blood pressure, electrolytes and renal function as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Regorafenib
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Regorafenib?
MediHelp rates the interaction as minor. Chlorothiazide and Regorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Regorafenib inhibits BCRP and could raise exposure to BCRP substrates. Chlorothiazide is not a well-established BCRP substrate, so a meaningful effect is doubtful.
How serious is the interaction between Chlorothiazide and Regorafenib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Monitor blood pressure, electrolytes and renal function as usual.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
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