Drug interactions
Chlorothiazide + Sulindac
Severity: Moderate
Chlorothiazide and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the diuretic and antihypertensive efficacy of thiazides and, in volume-depleted patients, increase the risk of acute kidney injury. Thiazide-related hypokalemia is not reliably countered by the NSAID.
What this interaction means in plain words
Chlorothiazide and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorothiazide belongs to Cardiovascular; Sulindac belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis causes sodium retention and reduced renal perfusion, antagonising thiazide effects.
What to do
Monitor blood pressure, renal function and electrolytes after starting the NSAID. Ensure adequate hydration and use the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Sulindac?
MediHelp rates the interaction as moderate. Chlorothiazide and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the diuretic and antihypertensive efficacy of thiazides and, in volume-depleted patients, increase the risk of acute kidney injury. Thiazide-related hypokalemia is not reliably countered by the NSAID.
How serious is the interaction between Chlorothiazide and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes after starting the NSAID. Ensure adequate hydration and use the lowest effective dose.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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