Drug interactions
Chlorothiazide + Tolazamide
Severity: Moderate
Chlorothiazide and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorothiazide can raise blood glucose and blunt the effect of tolazamide, particularly at higher doses. Glycemic control may deteriorate in diabetic patients.
What this interaction means in plain words
Chlorothiazide and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorothiazide belongs to Cardiovascular; Tolazamide belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism, with thiazide-induced hypokalemia reducing insulin secretion and increasing insulin resistance.
What to do
Monitor blood glucose and serum potassium after starting chlorothiazide. Increase the antidiabetic regimen as needed and correct hypokalemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Tolazamide?
MediHelp rates the interaction as moderate. Chlorothiazide and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorothiazide can raise blood glucose and blunt the effect of tolazamide, particularly at higher doses. Glycemic control may deteriorate in diabetic patients.
How serious is the interaction between Chlorothiazide and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum potassium after starting chlorothiazide. Increase the antidiabetic regimen as needed and correct hypokalemia.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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