Drug interactions
Chlorothiazide + Umeclidinium-vilanterol
Severity: Moderate
Chlorothiazide and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both vilanterol (a beta2-agonist) and thiazide diuretics can lower serum potassium. Together they may produce hypokalemia and ECG changes, particularly with high doses or in patients with cardiac disease.
What this interaction means in plain words
Chlorothiazide and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorothiazide belongs to Cardiovascular; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive hypokalemia from beta2-mediated intracellular potassium shift and thiazide renal potassium loss.
What to do
Check serum potassium at baseline and periodically, and correct deficits; avoid exceeding the recommended vilanterol dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Chlorothiazide and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both vilanterol (a beta2-agonist) and thiazide diuretics can lower serum potassium. Together they may produce hypokalemia and ECG changes, particularly with high doses or in patients with cardiac disease.
How serious is the interaction between Chlorothiazide and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium at baseline and periodically, and correct deficits; avoid exceeding the recommended vilanterol dose.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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