Drug interactions
Chlorpheniramine + Cyclizine
Severity: Moderate
Chlorpheniramine and Cyclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating H1 antihistamines with anticholinergic properties, so together they can cause marked drowsiness, dry mouth and confusion, especially in older adults.
What this interaction means in plain words
Chlorpheniramine and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpheniramine belongs to Respiratory; Cyclizine belongs to Respiratory.
Why it happens
Additive H1 blockade, CNS depression and muscarinic antagonism.
What to do
Avoid concurrent use where possible, particularly in the elderly. Counsel on avoiding driving if both are taken.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpheniramine
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Chlorpheniramine with Cyclizine?
MediHelp rates the interaction as moderate. Chlorpheniramine and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating H1 antihistamines with anticholinergic properties, so together they can cause marked drowsiness, dry mouth and confusion, especially in older adults.
How serious is the interaction between Chlorpheniramine and Cyclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible, particularly in the elderly. Counsel on avoiding driving if both are taken.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
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