Drug interactions
Chlorpheniramine + Deutetrabenazine
Severity: Moderate
Chlorpheniramine and Deutetrabenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause somnolence, so combined use may increase drowsiness and impair alertness. Deutetrabenazine can also cause depression and parkinsonism, which may complicate assessment of sedation.
What this interaction means in plain words
Chlorpheniramine and Deutetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpheniramine belongs to Respiratory; Deutetrabenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression from H1-antihistamine sedation and VMAT2 inhibition.
What to do
Warn the patient about drowsiness and driving risk. Monitor for excessive sedation and consider a non-sedating antihistamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpheniramine
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Chlorpheniramine with Deutetrabenazine?
MediHelp rates the interaction as moderate. Chlorpheniramine and Deutetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause somnolence, so combined use may increase drowsiness and impair alertness. Deutetrabenazine can also cause depression and parkinsonism, which may complicate assessment of sedation.
How serious is the interaction between Chlorpheniramine and Deutetrabenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn the patient about drowsiness and driving risk. Monitor for excessive sedation and consider a non-sedating antihistamine.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
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